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Anti-angiogenic therapy in pediatric brain tumors: an effective strategy?
Mariska Sie1, Wilfred F A den Dunnen2, Eelco W Hoving3
1Department of Pediatrics, Beatrix Children's Hospital, Pediatric Oncology/Hematology Division, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Abstract:
Brain tumors are still the leading cause of cancer morbidity and mortality among children, despite different therapeutic options including neurosurgery, chemotherapy and radiation. As angiogenesis is highly crucial in brain tumor growth and progression, numerous clinical trials evaluating diverse anti-angiogenic agents have been described. In the present review, we aimed to answer the question if anti-angiogenic therapy is an effective strategy in the treatment of children with brain tumors. Although some encouraging results have been published of anti-angiogenic therapy targeting vascular endothelial growth factor (VEGF)/VEGF receptor signaling or epidermal growth factor receptor (EGFR), still more insight is warranted to be highly conclusive about the efficacy of anti-angiogenic therapy with currently potential upcoming anti-angiogenic agents in pediatric brain tumors. However, given the need for new therapeutic strategies, multi targeted therapy with anti-angiogenic agents anticipating on possible tumor escape mechanisms could be effective in the future treatment of pediatric brain tumors.
Insights
Anti-angiogenic therapy shows promise for pediatric brain tumors by targeting tumor growth pathways like VEGF. Further research is needed to confirm efficacy and explore multi-targeted approaches for future treatments.
Area of Science:
- Pediatric Oncology
- Cancer Therapeutics
- Tumor Angiogenesis
Background:
- Brain tumors remain a primary cause of childhood cancer morbidity and mortality.
- Angiogenesis is critical for brain tumor growth and progression.
- Current treatments like surgery, chemotherapy, and radiation have limitations.
Purpose of the Study:
- To evaluate the effectiveness of anti-angiogenic therapy in treating pediatric brain tumors.
- To review existing clinical trials and emerging anti-angiogenic agents.
- To determine the potential of anti-angiogenic strategies in pediatric neuro-oncology.
Main Methods:
- Review of existing literature and clinical trials on anti-angiogenic therapy in pediatric brain tumors.
- Analysis of targeted therapies focusing on vascular endothelial growth factor (VEGF)/VEGF receptor and epidermal growth factor receptor (EGFR) signaling.
- Exploration of potential future therapeutic strategies.
Main Results:
- Some studies show encouraging results for anti-angiogenic therapies targeting VEGF/VEGF receptor and EGFR.
- Conclusive evidence on the efficacy of current anti-angiogenic agents in pediatric brain tumors is still lacking.
- The need for further investigation into novel anti-angiogenic agents is highlighted.
Conclusions:
- Anti-angiogenic therapy presents a potential avenue for treating pediatric brain tumors.
- More research is required to establish definitive efficacy and optimal use of these agents.
- Multi-targeted anti-angiogenic therapy may offer future therapeutic benefits by overcoming tumor resistance mechanisms.
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