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In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn(2+) fluorescent sensor with nuclear
Changli Zhang1, Zhipeng Liu, Yunling Li
1State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. heweij69@nju.edu.cn zguo@nju.edu.cn.
Chemical Communications (Cambridge, England)
|October 31, 2013
Abstract:
A newly developed fluorescent sensor, , shows a specific turn-on response to Zn(2+) and can be excited by visible light. The in situ nuclear Zn(2+) imaging in HeLa and HepG2 cells reveals the nuclear envelope penetrability of the sensor. The specific sensor location in a zebrafish larva was also demonstrated.
