Full blood count normal reference values for adults in France

Area of Science:

• Clinical Chemistry
• Hematology
• Reference Values

Background:

• Accurate full blood count (FBC) reference values are crucial for clinical diagnostics.
• Establishing precise FBC parameters requires careful consideration of preanalytical conditions and population demographics.

Purpose of the Study:

• To determine comprehensive normal reference values for full blood count (FBC) in adult populations.
• To provide updated FBC values that can be reliably used in clinical practice.

Main Methods:

• Defined FBC normal values in a large cohort of 33,258 healthy adults (19,612 men, 13,646 women).
• Excluded individuals with conditions that could affect FBC parameters to ensure population health.
• Collected data on FBC values stratified by sex and age groups (16-69 years and >69 years).

Main Results:

• Detailed FBC normal values are presented for standard parameters, segmented by sex and age.
• Specific FBC values are provided for adults aged 16 to 69 years.
• FBC values for healthy adults over 69 years old (n=339) without comorbidities are also included.

Conclusions:

• The established FBC normal values are proposed for routine clinical use.
• These values facilitate unambiguous differentiation between normal and pathological states.
• The reference values are applicable across mainland France.