Related Experiment Video
Updated: May 6, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Early recognition of Cushing's disease: a case study
Sherry L Iuliano1, Edward R Laws
1(Nurse Practitioner), Department of Neurosurgery, Pituitary/Neuroendocrine Center, Brigham and Women's Hospital, Boston, Massachusetts (Professor), Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Cushing's disease, a rare condition caused by excess cortisol, presents with symptoms like weight gain and fatigue. Early recognition by nurse practitioners is crucial for timely treatment and improved patient outcomes.
Area of Science:
- Endocrinology
- Case Study
Background:
- Cushing's disease results from pituitary overproduction of adrenocorticotropic hormone (ACTH), leading to excess cortisol.
- This condition is rare, predominantly affecting women, and can lead to serious comorbidities if untreated.
Observation:
- A case study of a 34-year-old woman with Cushing's disease highlights common clinical presentations.
- Symptoms included weight gain, facial changes, amenorrhea, and muscle wasting, posing diagnostic challenges.
Findings:
- The patient presented with multiple symptoms indicative of Cushing's disease.
- Diagnostic studies confirmed excess cortisol production due to ACTH overstimulation.
Implications:
- Early recognition and diagnosis by nurse practitioners are vital for effective management.
- Prompt treatment can reverse symptoms and improve quality of life, reducing risks of diabetes and hypertension.
Related Concept Videos
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Chronic Pancreatitis II: Collaborative Care
Assessment:
Huntington Disease l: Introduction
Hyperthyroidism I: Introduction

