Correlation between tissue metabolism and cellularity assessed by standardized uptake value and apparent diffusion...

Area of Science:

• Oncology
• Radiology
• Medical Imaging

Background:

• Peritoneal metastases significantly impact cancer patient prognosis.
• Accurate assessment of peritoneal metastases is crucial for treatment planning.
• Standardized uptake value (SUV) from FDG-PET/CT reflects metabolic activity, while apparent diffusion coefficient (ADC) from MRI indicates water diffusivity.

Purpose of the Study:

• To investigate the correlation between SUV and ADC in peritoneal metastases.
• To assess the relationship between tissue metabolism and water diffusivity in these lesions.

Main Methods:

• Prospective recruitment of patients with peritoneal dissemination detected on FDG-PET/CT.
• Performance of MRI examinations including diffusion-weighted imaging (DWI).
• Independent review of FDG-PET/CT and DWI/MRI images by two radiologists; manual ROI-based quantification of SUVmax/SUVmean and ADCmin/ADCmean.

Main Results:

• A significant negative correlation was observed between ADCmean and both SUVmax (r=-0.528, P=0.001) and SUVmean (r=-0.548, P=0.001).
• ADCmin also showed significant negative correlations with SUVmax (r=-0.508, P=0.002) and SUVmean (r=-0.513, P=0.002).
• DWI/MRI demonstrated high diagnostic performance (98% accuracy) for peritoneal metastasis detection, comparable to FDG-PET/CT.

Conclusions:

• A significant inverse correlation exists between SUV and ADC in peritoneal metastases.
• These findings suggest a relationship between metabolic activity and water diffusivity in peritoneal lesions.
• Both FDG-PET/CT and DWI/MRI are valuable tools for detecting peritoneal metastases.