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Updated: May 6, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

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SAA1 gene variants and childhood obesity in China

Xiao Zhang1, Qi-Zhu Tang, Ai-Ying Wan

  • 1Department of Pediatric, RenMin Hospital of Wuhan University, Jie Fang Road, Wuchang district, Wuhan 430060, China. xiaozhan_g@163.com.

Lipids in Health and Disease
|November 1, 2013
PubMed

Insights

Obesity in children is linked to SAA1 gene variations. Specific SAA1 polymorphisms, particularly rs4638289, were more frequent in obese children and correlated with higher SAA plasma levels.

Area of Science:

  • Genetics
  • Pediatrics
  • Metabolic Health

Background:

  • Obesity is a risk factor for insulin resistance and metabolic syndrome in children.
  • Serum amyloid A (SAA) is an apolipoprotein crucial for glucose and lipid homeostasis.

Purpose of the Study:

  • To investigate the association between SAA1 gene allelic variants and obesity in school-age children.
  • To explore the role of SAA1 polymorphisms in pediatric obesity and metabolic parameters.

Main Methods:

  • Study included 520 children aged 5-15 years, categorized as obese (BMI z score ≥1.65) or non-obese.
  • Genotyping of four SAA1 gene SNPs (rs12218, rs4638289, rs7131332, rs11603089) using PCR-RFLP.
  • Analysis of SAA levels, LDL-C, TG, and TC concentrations in relation to obesity and genotypes.

Main Results:

  • Obese children exhibited higher circulating SAA, LDL-C, TG, and TC levels compared to non-obese children.
  • Increased frequency of SAA1 polymorphisms rs12218 and rs4638289 was observed in obese children.
  • The rs4638289 polymorphism was significantly associated with elevated SAA plasma levels.

Conclusions:

  • SAA1 genetic polymorphisms are associated with obesity in Chinese children.
  • The rs4638289 variant may contribute to increased SAA levels and obesity risk.
Abstract

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