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Published on: March 8, 2018
Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2
Wenjin Xiao1, Yun Huang, Jixiang Dong
1Department of Endocrinology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
Background:
The relationship of platelet volume indices including mean platelet volume (MPV) and platelet distribution width (PDW) with carotid intima-media thickness (IMT) as well as vibration perception threshold (VPT) was investigated in type 2 diabetic patients.
Methods:
A total of 500 type 2 diabetic patients (298 male, 202 female) were enrolled. Clinical and laboratory data were collected from hospital records.
Results:
Both MPV and PDW were significantly associated with carotid IMT, after adjustment for confounding factors including age, systolic blood pressure, total cholesterol and creatinine (0.833 ± 0.029 mm vs. 0.955 ± 0.030 mm; 0.839 ± 0.029 mm vs. 0.955 ± 0.030 mm; P = 0.0015 and P = 0.022, respectively). Agreed with carotid IMT analysis results, significant association was found between PDW and VPT as tertiles (15.760 ± 1.091V vs 20.187 ± 1.094V, P = 0.016). In multivariable analysis, both MPV and PDW were significantly associated with VPT (P = 0.021 and P = 0.007, respectively). However, only PDW, but not MPV, was significantly associated with carotid IMT (P = 0.002).
Conclusions:
These findings implied the predictive value of platelets volume indices in vascular and peripheral neuropathy complications in type 2 diabetes.
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