Related Experiment Video

Updated: May 6, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

8.9K

Embryonic stem cells shed new light on the developmental roles of p53

Min Hwa Shin, Yunlong He, Jing Huang

    Cell & Bioscience
    |November 1, 2013
    PubMed

    Insights

    The tumor suppressor p53 is crucial for development, despite previous assumptions. New research in stem cells reveals its molecular mechanisms and connection to cancer suppression.

    Area of Science:

    • Developmental Biology
    • Molecular Biology
    • Cancer Research

    Background:

    • The role of p53 in development is debated, with knockout mice showing subtle defects but no major developmental issues.
    • p53 activation typically requires stress, complicating the understanding of its non-stress-related developmental functions.
    • Existing knowledge gaps exist regarding the molecular and cellular mechanisms underlying p53's developmental roles.

    Purpose of the Study:

    • To review recent studies on p53 in embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
    • To elucidate the molecular mechanisms behind p53's developmental roles.
    • To explore the relationship between p53's developmental functions and its tumor suppressive activity.

    Main Methods:

    • Review of recent scientific literature focusing on p53 in mouse and human ES and iPS cells.
    • Analysis of studies investigating molecular and cellular pathways involved in p53-mediated development.
    • Discussion of comparative data between developmental roles and tumor suppression.

    Main Results:

    • Emerging evidence supports significant developmental roles for p53.
    • Studies in ES and iPS cells provide new insights into p53's molecular and cellular functions during development.
    • A potential link between p53's developmental functions and its role in preventing cancer is suggested.

    Conclusions:

    • The molecular mechanisms governing p53's developmental roles are becoming clearer.
    • p53 plays a more significant role in development than previously understood.
    • The developmental functions of p53 are likely interconnected with its tumor suppressive capabilities.

    More Related Videos

    Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts10:04

    Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts

    Published on: January 8, 2017

    6.8K
    Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells08:52

    Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

    Published on: June 13, 2018

    8.3K

    Related Concept Videos

    Abnormal Proliferation02:23

    Abnormal Proliferation

    Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
    4.0K
    DNA Damage Can Stall the Cell Cycle02:36

    DNA Damage Can Stall the Cell Cycle

    In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
    2.4K
    DNA Damage can Stall the Cell Cycle02:36

    DNA Damage can Stall the Cell Cycle

    In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
    8.5K
    Negative Regulator Molecules01:23

    Negative Regulator Molecules

    Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
    32.1K
    Maintenance of the ES Cell State01:14

    Maintenance of the ES Cell State

    The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
    1.9K
    Embryonic Stem Cells00:58

    Embryonic Stem Cells

    Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
    25.9K