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Updated: May 6, 2026
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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
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Indications for keratoplasty in Nepal: 2005 - 2010
Summary
Infectious keratitis is the leading reason for corneal transplants, highlighting the need for better eye care to prevent blindness. This study analyzed 645 keratoplasty surgeries to understand current indications.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Public Health
Background:
- Corneal disease, particularly infective keratitis, is a significant cause of vision impairment and blindness globally.
- Developing countries face a high burden of corneal blindness due to limited access to primary eye care.
Purpose of the Study:
- To determine the current indications for keratoplasty (corneal transplantation).
- To analyze trends in keratoplasty indications over time.
- To compare these indications with global patterns.
Main Methods:
- A retrospective case series study of 645 keratoplasty surgeries performed on 589 patients.
- Data collected from January 2005 to December 2010 at the Tilganga Institute of Ophthalmology.
- Evaluation included demographic parameters, preoperative diagnoses, and surgical procedures.
Main Results:
- Active infectious keratitis (40.9%) was the most frequent indication for keratoplasty.
- Corneal opacity (26.8%) and regrafts (11.2%) were other significant reasons for surgery.
- Indications varied by age, with infectious keratitis dominant overall, bullous keratopathy in older patients, and keratoconus/scarring in children.
Conclusions:
- Active or healed keratitis remains the primary indication for keratoplasty.
- There is a critical need for enhanced primary eye healthcare to reduce the incidence of corneal blindness.
- Addressing infectious keratitis is key to lowering the prevalence of corneal blindness.
