Related Experiment Video
Updated: May 6, 2026
09:06
Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research
Published on: March 29, 2024
1.3K
Update on therapy for superficial mycoses: review article part I
Maria Fernanda Reis Gavazzoni Dias1, Maria Victória Pinto Quaresma-Santos, Fred Bernardes-Filho
1Rubem David Azulay Institute of Dermatology, Santa Casa de Misericórdia do Rio de Janeiro.
Anais Brasileiros De Dermatologia
|November 1, 2013
Summary
Superficial fungal infections affect hair, skin, and nails globally. This article reviews current topical and systemic treatments for mycoses, including new antifungal alternatives.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Superficial fungal infections (mycoses) of the hair, skin, and nails are a significant global health concern.
- Treatment selection is complicated by potential drug interactions and adverse effects.
- Common superficial mycoses include keratophytoses, dermatophytosis, and candidiasis.
Purpose of the Study:
- To provide a practical overview of current treatments for superficial fungal infections.
- To discuss commonly used topical and systemic antifungal drugs, including dosage and duration.
- To highlight emerging antifungal therapies and market availability.
Main Methods:
- Review of established and novel therapeutic options for superficial mycoses.
- Analysis of drug interactions and side effect profiles.
- Examination of treatments available in Brazilian and global markets.
Main Results:
- Detailed discussion of topical and systemic treatments for dermatophytosis, candidiasis, and keratophytoses.
- Information on drug dosages and treatment durations provided.
- Emerging antifungal alternatives and their market presence are identified.
Conclusions:
- Effective management of superficial fungal infections requires careful consideration of treatment options.
- Understanding drug interactions and side effects is crucial for safe and effective therapy.
- Newer antifungal agents offer promising alternatives for managing mycoses.
Related Concept Videos
01:23Skin Diseases and Disorders
5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
01:15Antifungal Agents
132
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
132
01:28Fungal Phylum Microsporidia
787
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
787
02:49Cancer Therapies
8.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.6K
01:18Endocarditis III: Medical Management
390
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
390
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
2.5K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
2.5K