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Understanding the type 1 reactional state for early diagnosis and treatment: a way to avoid disability in leprosy
José Augusto da Costa Nery1, Fred Bernardes Filho, Juliana Quintanilha
1Departament of Mycobacteriosis, Leprosy Laboratory of the Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de JaneiroRJ, Brazil.
Abstract:
A type 1 reaction or reversal reaction is expressed clinically by inflammatory exacerbation of the skin lesions and nerve trunks, consequently leading to sensory and motor alterations. It occurs in non-polar forms of leprosy, although it can occur in a small percentage of sub-polar LL treated patients. Disabilities, deformities and morbidity, still present in leprosy, are mainly caused by these acute episodes. The recognition of reactional states is imperative for an early approach and efficient management, to avoid the emergence of disabilities that stigmatize the disease. This review aims to describe the clinical aspects, immunopathogenesis, epidemiology, histopathological features and therapeutics of type 1 reactions.
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