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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: May 6, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Atrophic dermatofibroma.

Amanda Nascimento C de Macedo Mota1, Violeta Duarte Tortelly, Daniel Lago Obadia

  • 1Pedro Ernesto University Hospital, Rio de Janeiro State University, Rio de JaneiroRJ, Brazil.

Anais Brasileiros De Dermatologia
|November 1, 2013
PubMed
Summary
This summary is machine-generated.

Atrophic dermatofibroma is a rare variant of a common skin tumor. This case highlights its unique clinical and histopathological features, suggesting it may be underdiagnosed.

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Dermatofibroma is a common benign fibrohistiocytic tumor.
  • Classical presentations are easily diagnosed.
  • The atrophic variant's origin is uncertain.

Observation:

  • Clinically, this variant presents as a flat, atrophic, and depressible lesion.
  • Histopathology reveals reduced dermal thickness and elastic fibers.
  • This case represents a typical example of this uncommon variant.

Findings:

  • The atrophic variant of dermatofibroma exhibits distinct clinical and histological characteristics.
  • Reduced dermal thickness and elastic fiber content are key histopathological findings.
  • This variant is likely underdiagnosed due to its uncommon presentation.

Implications:

  • Increased awareness of the atrophic variant is needed for accurate diagnosis.
  • Further research into the etiology of this variant is warranted.
  • This case contributes to the understanding of dermatofibroma heterogeneity.