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Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
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Right ventricular outflow tract function in chronic obstructive pulmonary disease
Herz
|November 1, 2013
Summary
Right ventricular outflow tract (RVOT) systolic function, measured by RVOT fractional shortening (RVOT-FS), is impaired in patients with chronic obstructive pulmonary disease (COPD). This noninvasive measure correlates with functional capacity, aiding in cardiovascular risk assessment for COPD patients.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Evaluating right ventricular (RV) overload severity is crucial in chronic obstructive pulmonary disease (COPD) due to associated RV structural and functional changes.
- Noninvasive assessment of RV function is essential for determining RV load and cardiovascular risk in COPD patients.
Purpose of the Study:
- To investigate the clinical utility of right ventricular outflow tract (RVOT) systolic function, assessed via transthoracic echocardiography, in COPD patients.
Main Methods:
- Prospective study comparing male COPD patients with healthy male non-smoking controls.
- Echocardiographic assessment included conventional RV parameters, RVOT size, and RVOT fractional shortening (RVOT-FS).
Main Results:
- RVOT-FS was significantly impaired in COPD patients (27.8±15.5%) compared to controls (57.5±8.6%, p<0.001).
- RVOT-FS correlated positively with tricuspid annular plane systolic excursion (TAPSE) and pulmonary acceleration time, and inversely with pulmonary artery systolic pressure and functional capacity.
- Significant differences in RVOT-FS were observed across COPD subgroups based on New York Heart Association functional classification (p<0.001).
Conclusions:
- RVOT-FS is a simple, noninvasive measure of RV systolic function in COPD patients, showing a strong correlation with functional capacity.
- Combining RVOT-FS with TAPSE and transtricuspid Doppler analysis offers a comprehensive evaluation of RV performance in COPD.
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