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Updated: May 6, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Defining and mapping the person with osteoarthritis for population studies and public health
Elaine Thomas1, George Peat, Peter Croft
1Arthritis Research UK Primary Care Centre, Keele University, North Staffordshire ST5 5BG, UK. e.thomas@keele.ac.uk.
Objective:
To determine population-based estimates for the prevalence of the person with OA, predicted to be the single greatest cause of disability in the general population by 2030, in order to inform the planning and commissioning of health, social care and prevention services.
Methods:
A postal survey to all adults ≥50 years of age registered with eight general practices in the UK. Self-reported data on chronic joint pain in four body regions (hand, hip, knee, foot) and the disabling nature of the pain was collected to determine gender and age-group specific prevalence estimates of clinical OA in the joint region and in the person. Multiple imputation and weighted logistic regression was used to allow for missing data.
Results:
A total of 26 705 mailed surveys resulted in 18 474 responses (adjusted response = 71.8%). Approximately half of the mailed population had OA in at least one of the four regions (53.23%, 95% CI 52.3, 54.1) and less than half of these had disabling OA (21.87%, 95% CI 21.2, 22.5). The more joint regions involved, the more likely that the OA was disabling. OA prevalence was higher in females and increased with age. Applied to the population of England, this yielded an estimated 3.5 million persons with disabling OA, including 1.45 million people between 50 and 65 years of age and 370 000 ≥85 years of age.
Conclusions:
A simple approach to defining the person with OA can contribute to population comparisons, public health projections and health care needs assessments.
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