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Invited commentary: Body mass index and mortality.
American Journal of Epidemiology
|November 1, 2013
Summary
Higher body mass index (BMI) and weight gain in adulthood are linked to increased mortality risk. This finding contrasts with some studies suggesting overweight may offer slight protection.
Area of Science:
- Epidemiology
- Public Health
- Clinical Research
Background:
- Obesity epidemic necessitates understanding body mass index (BMI) and mortality links.
- Previous research shows conflicting results regarding overweight and obesity's impact on mortality.
Purpose of the Study:
- To examine associations between BMI at different adult ages and mortality.
- To investigate the effect of weight gain between early and middle adulthood on subsequent mortality.
Main Methods:
- Analysis of a subsample (109,947 individuals) from the National Institutes of Health-AARP Diet and Health Study cohort.
- Examined BMI at ages 18, 35, and 50, and weight gain between these ages.
- Follow-up period of 12.5 years to assess mortality.
Main Results:
- A positive association was found between BMI and mortality at each measured age.
- Significant positive associations were observed between weight gain (ages 18-35 and 35-50) and mortality.
- Achieving a BMI of 25 or higher at younger ages increased the risk of death.
Conclusions:
- Higher BMI and substantial weight gain in adulthood are associated with increased mortality.
- Findings challenge some previous meta-analyses suggesting overweight may be protective.
- Highlights the need for careful consideration of BMI limitations and mortality measures in clinical practice.
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