Cardiogenic diabetes

Maya Guglin1, Arnaldo Villafranca, Anthony Morrison

  • 1Department of Cardiology, University of South Florida, Tampa, FL, USA, mguglin@gmail.com.

Heart Failure Reviews
|November 1, 2013
PubMed

Insights

Diabetes mellitus is a known risk factor for heart failure. Recent evidence suggests heart failure may also increase the risk of developing new-onset diabetes, a connection explored in this review.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetes mellitus is a well-established risk factor for heart failure.
  • Emerging research indicates a potential bidirectional relationship between heart failure and diabetes.
  • Insulin resistance is a common finding in patients with heart failure.

Purpose of the Study:

  • To review and summarize existing literature on the incidence of new-onset diabetes in heart failure patients.
  • To analyze the evidence supporting the hypothesis that heart failure predisposes individuals to diabetes.
  • To consolidate findings on the link between heart failure and the development of diabetes mellitus.

Main Methods:

  • Literature review of studies investigating the relationship between heart failure and diabetes.
  • Analysis of reported incidence rates of new-onset diabetes in heart failure populations.
  • Synthesis of evidence from existing research to assess the connection.

Main Results:

  • Evidence suggests a higher incidence of new-onset diabetes among individuals with heart failure.
  • The review consolidates findings that support the predisposition of heart failure to diabetes.
  • While intuitive due to insulin resistance, direct confirming evidence remains relatively scarce.

Conclusions:

  • Heart failure appears to be associated with an increased risk of developing new-onset diabetes.
  • Further research is needed to fully elucidate the mechanisms and confirm the causal link.
  • Understanding this relationship is crucial for comprehensive patient management in both conditions.

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
57
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and...
57
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
837