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Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
03:39

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates

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Improving genome assemblies and annotations for nonhuman primates.

Robert B Norgren

    ILAR Journal
    |November 1, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Improving nonhuman primate genomes using Next Generation sequencing is crucial for biomedical research and understanding human evolution. High-quality reference genomes will significantly advance translational medicine and NHP research capabilities.

    Keywords:
    ape, evolutiongenome annotationgenome assemblylemurmonkeynonhuman primatestranslational research

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    Area of Science:

    • Genomics
    • Evolutionary Biology
    • Translational Medicine

    Background:

    • Nonhuman primates (NHPs) are vital models for human evolution and biomedical research, particularly in translational medicine.
    • Current draft nonhuman primate genomes have significant errors, limiting their utility for evolutionary studies and Next Generation (NextGen) sequencing applications.
    • NHP genomes are essential for advancing biomedical research and understanding human evolutionary history.

    Purpose of the Study:

    • To outline strategies for improving the quality of nonhuman primate genomes using Next Generation sequencing technologies.
    • To enhance the utility of NHP models in biomedical research and evolutionary studies.
    • To establish high-quality reference genomes for nonhuman primates.

    Main Methods:

    • Supplementing existing Sanger sequences with NextGen whole genome and exomic sequencing data.
    • Improving scaffold-to-chromosome assignments through physical mapping and gene structure information.
    • Utilizing mRNA-sequence data for cost-effective transcriptome acquisition and genome annotation.

    Main Results:

    • NextGen sequencing can generate more complete and accurate NHP genome assemblies and annotations.
    • A modest investment in sequencing and time can yield reference-grade NHP genomes.
    • Improved NHP genomes will overcome current technological constraints and transform research.

    Conclusions:

    • Enhanced nonhuman primate genomes are achievable and essential for advancing biomedical research and evolutionary studies.
    • The integration of NextGen sequencing offers a transformative approach to NHP genomics.
    • High-quality NHP reference genomes will significantly benefit translational medicine and scientific discovery.