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Related Concept Videos

Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

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The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
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Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

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Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

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Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
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Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

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The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
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ER Retrieval Pathway01:45

ER Retrieval Pathway

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In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
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Related Experiment Video

Updated: May 6, 2026

Visualizing Intracellular SNARE Trafficking by Fluorescence Lifetime Imaging Microscopy
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A sustained passion for intracellular trafficking.

Elizabeth A Miller1

  • 1Department of Biological Sciences, Columbia University, New York, NY 10027.

Molecular Biology of the Cell
|November 1, 2013
PubMed
Summary

This award highlights a fulfilling career in cell biology, demonstrating that passion and interest, not a rigid plan, can lead to success in science. Following your scientific curiosity can sustain a rewarding career path.

Area of Science:

  • Cell Biology
  • Scientific Community Engagement

Background:

  • Recipient of the Women in Cell Biology Sustained Excellence in Research Award.
  • Long-standing involvement in the American Society for Cell Biology community since graduate studies.

Discussion:

  • A successful scientific career can be built on following personal interests and passions.
  • A "grand plan" is not a prerequisite for a fulfilling and impactful career in science.
  • Career paths in science may involve natural "migration" between areas.

Key Insights:

  • Personal passion and curiosity are strong drivers for a sustainable and successful scientific career.
  • Flexibility and adaptability in career trajectory are valuable assets in scientific research.
  • The American Society for Cell Biology fosters a supportive community for scientists.

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Outlook:

  • Encouraging future scientists to pursue their interests.
  • Promoting diverse and adaptable career pathways in cell biology.
  • Highlighting the importance of community and mentorship in scientific development.