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Experimental RNAi02:15

Experimental RNAi

6.5K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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RNA Interference01:23

RNA Interference

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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

13.4K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
13.4K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

14.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Related Experiment Video

Updated: May 6, 2026

Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus
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Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus

Published on: December 28, 2016

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Ribonucleic acid interference induced gene knockdown.

Sruthima N V S Gottumukkala1, C D Dwarakanath, Sabitha Sudarsan

  • 1Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Journal of Indian Society of Periodontology
|November 1, 2013
PubMed
Summary
This summary is machine-generated.

Complete periodontal regeneration remains challenging. Ribonucleic acid interference (RNAi) offers a novel RNA-based approach for periodontal management, exploring its mechanisms and applications in dental research for future regenerative therapies.

Keywords:
Gene knock downperiodontal regenerationribonucleic acid interferencesmall interfering ribonucleic acid

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Area of Science:

  • Periodontal regeneration
  • Tissue engineering
  • RNA-based therapeutics

Background:

  • Despite advances, complete periodontal regeneration is not consistently achievable in humans.
  • Stem cell identification and tissue engineering concepts are advancing periodontal regenerative medicine.
  • Ribonucleic acid interference (RNAi) presents a novel RNA-based strategy for periodontal treatment.

Purpose of the Study:

  • To summarize the mechanisms of RNAi.
  • To review current in vitro and in vivo applications of RNAi in dental research.
  • To explore the future potential of RNAi in periodontal regeneration.

Main Methods:

  • Literature review of RNAi mechanisms.
  • Analysis of existing in vitro studies on RNAi in dental research.
  • Evaluation of in vivo studies demonstrating RNAi applications in dentistry.

Main Results:

  • RNAi mechanisms provide a basis for targeted gene silencing.
  • In vitro and in vivo studies show promising applications of RNAi in dental research.
  • These applications suggest potential for future periodontal regeneration strategies.

Conclusions:

  • RNAi is a promising novel approach for periodontal management.
  • Further research into RNAi mechanisms and applications is warranted for periodontal regeneration.
  • RNAi holds potential for future advancements in regenerative dentistry.