Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Whipple's disease.

M Feldman

    The American Journal of the Medical Sciences
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Whipple's disease, a rare bacterial infection, is now treatable with antibiotics, though its causative agent remains elusive. This review covers its systemic effects, diagnosis, and management.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides.

    Nature medicine·1995
    Same author

    Combined vaccination with major histocompatibility class I and interleukin 2 gene-transduced melanoma cells synergizes the cure of postsurgical established lung metastases.

    Cancer research·1995
    Same author

    Interleukin-6: effects on tumor models in mice and on the cellular regulation of transcription factor IRF-1.

    Annals of the New York Academy of Sciences·1995
    Same author

    Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes.

    Cell·1995
    Same author

    Rop and Ras2, members of the Sec1 and Ras families, are localized in the outer membranes of labyrinthine channels and vesicles of Drosophila nephrocyte, the Garland cell.

    European journal of cell biology·1995
    Same author

    Fatal disseminated herpes simplex II infection in a patient with systemic lupus erythematosus.

    The Journal of rheumatology·1995
    Same journal

    Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

    The American journal of the medical sciences·2026
    Same journal

    In Memoriam: Maurice A. Mufson, MD, MACP.

    The American journal of the medical sciences·2026
    Same journal

    Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

    The American journal of the medical sciences·2026
    Same journal

    Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

    The American journal of the medical sciences·2026
    Same journal

    Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

    The American journal of the medical sciences·2026
    Same journal

    The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

    The American journal of the medical sciences·2026
    See all related articles

    Area of Science:

    • Infectious Diseases
    • Gastroenterology
    • Microbiology

    Background:

    • Whipple's disease is a rare, systemic bacterial infection.
    • Historically fatal, it is now treatable with antibiotics.
    • The causative organism, Whipple's bacillus, is difficult to culture, and its exact nature is unknown.

    Purpose of the Study:

    • To review the clinical manifestations, diagnosis, and treatment of Whipple's disease.
    • To discuss the systemic involvement of Whipple's disease beyond the gastrointestinal tract.
    • To address controversies regarding immunologic dysfunction in Whipple's disease.

    Main Methods:

    • Literature review of clinical manifestations.
    • Review of diagnostic approaches.
    • Analysis of current treatment strategies and antibiotic efficacy.

    Related Experiment Videos

    Main Results:

    • Whipple's disease affects multiple organ systems, including the gastrointestinal tract, lymph nodes, joints, nervous system, and heart.
    • Antibiotic therapy is effective in most cases, significantly improving outcomes.
    • Diagnosis relies on clinical suspicion, imaging, and characteristic histopathology.

    Conclusions:

    • Whipple's disease, while rare, is a treatable systemic infection.
    • Early diagnosis and appropriate antibiotic treatment are crucial for patient outcomes.
    • Further research is needed to fully elucidate the causative agent and the role of immunity.