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Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

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Primary cardiac angiofibroma.

Young Ju Kim¹, Young Jin Kim, Se Hoon Kim

¹Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Korean Circulation Journal

|November 1, 2013

Summary

This summary is machine-generated.

This case report details an intracardiac angiofibroma, a rare heart tumor. Surgical removal and analysis confirmed benign vascular growths, distinguishing it from common cardiac tumors.

Keywords:

Cardiac tumor Magnetic resonance imaging

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Area of Science:

Cardiovascular Pathology
Surgical Oncology
Diagnostic Imaging

Background:

Intracardiac tumors are rare, with cardiac angiofibroma being exceptionally uncommon.
Only four cases of intracardiac angiofibroma have been previously documented in medical literature.
This report presents a unique case of this rare tumor.

Purpose of the Study:

To describe a newly diagnosed case of intracardiac angiofibroma.
To differentiate its characteristics from other common cardiac tumors.
To highlight diagnostic and histological findings.

Main Methods:

Incidental diagnosis via echocardiography in a 57-year-old female.
Comprehensive cardiac imaging, including MRI.
Surgical excision and detailed histological examination of the mass.

Main Results:

The intracardiac angiofibroma presented as a left ventricle mass.
Cardiac MRI revealed specific signal intensities (high on T1/T2, low central core).
Histology confirmed benign vascular proliferation with collagen deposition, distinct from fibroma, myxoma, or angiosarcoma.

Conclusions:

Cardiac angiofibroma is a rare benign intracardiac tumor with distinct imaging and histological features.
This case expands the understanding of intracardiac angiofibroma.
Accurate diagnosis requires a combination of imaging and histopathology.