Related Experiment Video
Updated: May 6, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Silent brain infarction in the presence of systemic vascular disease
Julia Slark1, Paul Bentley, Pankaj Sharma
1Imperial College Cerebrovascular Research Unit (ICCRU), Department of Clinical Neurology, Imperial College London , London W6 8RF , UK.
Objective:
To determine the prevalence of asymptomatic brain ischaemic in the presence of vascular disease in other arterial territories.
Design:
Studies up to January 2011 were identified through comprehensive search strategies. Arcsine transformation for meta-analysis was used to calculate the standardized mean difference (SMD) and 95% confidence intervals (CI).
Setting:
A systematic review and meta-analysis were performed.
Participants:
For each study, the proportion of patients positive for SBI in the presence of other systemic vascular disease was extracted and analyzed.
Main Outcome Measures:
Using a random-effects model, a pooled effect estimate interpreted as a percentage prevalence of disease was calculated.
Results:
SBI in the presence of acute ischaemic stroke was found in 23% (SMD 0.99; P < 0.001; 95% CI 0.88-1.10); a 35% prevalence was found in patients with coronary artery disease (SMD 1.26; P < 0.001; 95% CI 0.95-1.58); and a 14% prevalence in patients with peripheral artery disease (SMD 0.48; P < 0.002; 95% CI 0.42-0.54), although the data-set in the latter is smaller.
Conclusions:
Patients with systemic vascular disease are at an increased risk of silent brain infarction.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Ischemic Stroke l: Introduction
Transient Ischemic Attack l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Hemorrhagic Stroke l: Introduction

