Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrons01:10

Nephrons

8.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.5K
Diabetic Nephropathy01:28

Diabetic Nephropathy

52
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
52
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.2K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

108
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

2.4K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How Contaminated Is the Surgical Field in Reverse Total Shoulder Arthroplasty? A Preliminary Quantitative Intraoperative Microbiological Study.

Journal of clinical medicine·2026
Same author

Risk Stratification for Late-Onset CMV Infection Following Prophylaxis With Letermovir in Allogeneic Stem Cell Transplant Recipients: Unraveling the Potential Role of CMV-Specific Cell-Mediated Immunity.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Evaluation of cefepime/enmetazobactam gradient strip and disk diffusion test for CTX-M-producing Enterobacterales.

Journal of global antimicrobial resistance·2026
Same author

Rapid AST in practice - a workflow analysis of the QuickMIC<sup>®</sup> rapid AST system at multiple clinical laboratories in Europe.

Frontiers in cellular and infection microbiology·2026
Same author

Long-term neurological outcomes after extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest: a 14-year single-centre cohort study.

Resuscitation·2026
Same author

In vivo emergence of cross-resistance to ceftazidime/avibactam and cefiderocol through selection of KPC variants in Klebsiella pneumoniae clinical isolates.

International journal of antimicrobial agents·2026

Related Experiment Video

Updated: May 6, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

8.3K

Polyomavirus-associated nephropathy.

Cristina Costa1, Rossana Cavallo

  • 1Cristina Costa, Rossana Cavallo, Virology Unit, University Hospital San Giovanni Battista di Torino, 10126 Turin, Italy.

World Journal of Transplantation
|November 1, 2013
PubMed
Summary

Polyomaviruses BK and JC are common, persisting latently and reactivating in kidney transplant recipients, causing polyomavirus-associated nephropathy (PVAN). Early monitoring of viral load and immune response is crucial for managing PVAN and preventing graft loss.

Keywords:
Cellular immune responseImmunosuppressive therapyKidney transplantationPolyomavirusVirological monitoring

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K
Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

9.6K

Related Experiment Videos

Last Updated: May 6, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

8.3K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K
Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

9.6K

Area of Science:

  • Virology
  • Immunology
  • Nephrology

Background:

  • Polyomaviruses BK and JC are widespread, establishing latent infections primarily in the urinary tract.
  • Reactivation can cause asymptomatic viruria or lead to polyomavirus-associated nephropathy (PVAN) in kidney transplant recipients.

Purpose of the Study:

  • To describe the features, pathogenesis, and management of PVAN.
  • To highlight the importance of early detection and monitoring for preventing graft loss.

Main Methods:

  • Review of polyomavirus BK and JC characteristics.
  • Discussion of PVAN etiology, pathogenesis, and clinical presentation.
  • Emphasis on viro-immunological monitoring strategies.

Main Results:

  • PVAN affects 1%-10% of renal transplant patients, with 30%-80% experiencing graft loss.
  • BK virus is the primary cause of PVAN, with JC virus implicated in a smaller percentage.
  • Immunosuppression is a key factor in PVAN development.

Conclusions:

  • Early identification of viral reactivation through polyomavirus load monitoring is essential.
  • Viro-immunological monitoring can identify high-risk patients for PVAN.
  • Management focuses on immune modulation due to the lack of specific antiviral therapies.