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Reprogramming the host: Modification of cell functions upon viral infection
Gualtiero Alvisi1, Giorgio Palù
1Gualtiero Alvisi, Giorgio Palù, Department of Molecular Medicine, Microbiology Section, 35121 Padua, Italy.
World Journal of Virology
|November 1, 2013
Summary
Viruses reprogram host cells to replicate, hijacking cellular machinery and evading defenses. This viral reprogramming alters cell functions, leading to pathogenic consequences.
Area of Science:
- Virology
- Cell Biology
- Molecular Biology
Background:
- Viruses and hosts co-evolve, with viruses exploiting host cell machinery for replication.
- Viral replication involves viral products and host factors, occurring in various cellular compartments.
- Viruses must ensure effector localization and evade host defenses.
Purpose of the Study:
- To highlight recent advances in understanding viral modulation of host cell functions.
- To explore how viruses reprogram cellular processes for replication and propagation.
- To discuss the pathogenic consequences of viral infections on host cells.
Main Methods:
- Review of current research in virology and cell biology.
- Analysis of viral strategies for host cell manipulation.
- Examination of subcellular localization and host defense evasion mechanisms.
Main Results:
- Viruses utilize host biosynthetic machinery for genome replication.
- Viral replication can occur in diverse cellular locations, including virus-induced membranes.
- Viruses modulate host post-translational modification for functional alterations.
Conclusions:
- Viral infection leads to profound modifications in cellular and viral product functions.
- Altered cellular differentiation and growth properties are observed during viral infections.
- Understanding viral reprogramming is crucial for comprehending pathogenesis.
Keywords:
CancerDifferentiationHepatitis C virusHuman immunodeficiency virusPathogenesisPost translational modificationRNAiViral factoriesVirus-host interactionMore Related Videos
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