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Collapsing focal segmental glomerulosclerosis: Current concepts.

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Collapsing focal segmental glomerulosclerosis (cFSGS), a distinct kidney disease, presents unique pathological features and clinical challenges. Increased awareness and research are crucial for better diagnosis and management of this condition.

Keywords:
Collapsing focal segmental glomerulosclerosisEnd-stage renal diseaseEtiologyPathologyPrognosisRenal biopsy

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Area of Science:

  • Nephrology
  • Pathology
  • Renal Medicine

Background:

  • Collapsing focal segmental glomerulosclerosis (cFSGS), or collapsing glomerulopathy, is a distinct morphological entity within FSGS.
  • Characterized by glomerular capillary collapse, podocyte hypertrophy/hyperplasia, and tubulointerstitial disease.
  • Etiology remains elusive, but it's associated with various diseases and conditions.

Purpose of the Study:

  • To highlight the unique pathological and clinical features of cFSGS.
  • To discuss the current understanding of its pathogenesis and clinical implications.
  • To emphasize the need for increased awareness and improved diagnostic/management strategies.

Main Methods:

  • Review of pathological findings in cFSGS.
  • Analysis of clinical presentation and outcomes.
  • Discussion of current research on pathogenesis and treatment.

Main Results:

  • cFSGS exhibits distinct morphology differing from other FSGS variants.
  • Associated with high incidence of nephrotic syndrome, rapid progression to ESRD, and poor treatment response.
  • Increasing recognition globally, including tropical regions, with potential for recurrence post-transplant.

Conclusions:

  • cFSGS requires greater recognition among healthcare professionals for accurate diagnosis.
  • Further research into pathogenesis is needed for targeted therapies.
  • Improved awareness and management are essential, particularly in developing countries.