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Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients

Yao-Peng Hsieh1, Ching-Hui Huang, Chia-Ying Lee

  • 1Yao-Peng Hsieh, Chia-Chu Chang, Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua City 500, Taiwan.

World Journal of Nephrology
|November 1, 2013
PubMed

Insights

Lower serum hepcidin levels are linked to increased left ventricular mass index in chronic kidney disease (CKD) patients. This association suggests potential cardiovascular risks in the CKD population.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is associated with cardiovascular complications.
  • Left ventricular mass index (LVMI) is a marker of cardiac remodeling and cardiovascular risk.
  • Hepcidin, a key regulator of iron metabolism, has been implicated in various disease states.

Purpose of the Study:

  • To investigate the relationship between serum hepcidin-25 levels and left ventricular mass index (LVMI) in patients with chronic kidney disease (CKD).

Main Methods:

  • A cross-sectional study involving 146 patients with stages 1-5 CKD.
  • Serum hepcidin-25 levels were measured.
  • Two-dimensional echocardiography was used to assess left ventricular mass (LVM) and LVMI.
  • Statistical analyses, including multivariate regression, were performed to determine independent associations.

Main Results:

  • Serum hepcidin-25 levels showed a trend of increase with CKD progression.
  • A significant negative correlation was observed between serum hepcidin-25 levels and LVMI (P = 0.005).
  • Decreased serum hepcidin-25 was independently associated with higher LVMI after adjusting for covariates (β = -0.28, P = 0.006).

Conclusions:

  • Lower serum hepcidin-25 levels are independently associated with increased LVMI in CKD patients.
  • These findings suggest that low hepcidin may contribute to adverse cardiovascular remodeling in CKD.
  • Further research is warranted to explore the clinical implications of this association for cardiovascular outcomes.
Abstract

Keywords:
Chronic kidney diseaseFerritinHepcidin-25Left ventricular massLeft ventricular mass index

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