Survival in the Australian chronic kidney disease population: potential effects of the CHOIR and CREATE studies

Area of Science:

• Nephrology
• Hematology
• Clinical Research

Background:

• The CHOIR (Correction of Hemoglobin and Iron Levels in Chronic Kidney Disease) and CREATE (Can Renin-Angiotensin-Aldosterone System Inhibition Improve Anemia in Chronic Kidney Disease) studies significantly altered global hemoglobin targets for chronic kidney disease (CKD) patients.
• Prior to these studies, anemia management in CKD was a significant clinical challenge.

Purpose of the Study:

• To evaluate the impact of the CHOIR and CREATE studies on hemoglobin levels and patient survival in a real-world setting.
• To assess trends in anemia management and outcomes for CKD patients following the publication of pivotal trial data.

Main Methods:

• Data were retrospectively extracted from Australia's Renal Anaemia Database.
• The study cohort included patients with chronic kidney disease between October 2000 and December 2009.
• Survival analysis was performed comparing patient cohorts based on their time of death relative to the study period.

Main Results:

• Survival rates showed a significant improvement in patients who died between 2007 and 2009 compared to those who died between 2000 and 2006.
• These findings suggest a positive correlation between the implementation of new hemoglobin targets and improved patient survival.

Conclusions:

• The changes in hemoglobin targets, driven by the CHOIR and CREATE studies, appear to have had a beneficial effect on the survival of patients with chronic kidney disease.
• This real-world data supports the clinical significance of updated anemia management guidelines in CKD care.