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Salvage stereotactic radiosurgery for brain metastases
George Klironomos1, Mark Bernstein
1Department of surgery, University of Toronto, Clinical Fellow in Neuroncology and Skull Base Neurosurgery, 339 Bathurst Street, Toronto, ON M5T2S8, Canada.
Expert Review of Neurotherapeutics
|November 2, 2013
Summary
Salvage stereotactic radiosurgery is a common and safe treatment for recurrent brain metastases, showing good local control and survival in patients. Further randomized trials are needed to establish optimal patient selection and treatment guidelines.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Increased cancer patient survival leads to a rise in recurrent or progressive brain metastases.
- Salvage stereotactic radiosurgery (SRS) is a frequently employed treatment for these cases.
Observation:
- Class III evidence indicates SRS provides satisfactory local brain control and survival for patients with relapsing brain disease.
- Stereotactic radiosurgery is generally a safe procedure with a low incidence of neurological toxicity.
Findings:
- Existing studies, primarily observational, suggest positive outcomes for salvage SRS in brain metastases.
- The safety profile of SRS is favorable, with minimal reported brain toxicity.
Implications:
- Randomized, prospective studies are essential to definitively evaluate salvage SRS efficacy and safety.
- Establishing clear guidelines for patient selection is crucial given the growing number of patients with relapsing brain metastases.
