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Updated: May 6, 2026
Development and Angiographic Use of the Rabbit VX2 Model for Liver Cancer
Published on: January 7, 2019
BCRP expression in VX2 rabbit liver tumours and its effects on tumour recurrence, metastasis and treatment
Cai-Xia Li1, Kai Zhang, Fu-Bo Xie
1Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, China
Objective:
This study aimed to investigate the effects of BCRP expression on tumor recurrence, metastasis and treatment tolerability.
Methods:
A VX2 rabbit liver tumor model was established. Division was randomly into 4 groups: namely saline control group; A group, given hydration lipiodol; B group, Ad-p53; and C group, Ad-p53+hydration lipiodol. After the intervention, samples were collected to detect the BCRP, MMP-2, VEGF and PCNA.
Results:
The expression of BCRP, MMP-2, PCNA and VEGF in tumors in Group A had no significant difference when compared with the control group, while in B and C group, the values were significantly lower (P < 0.05). BCRP positive expression in metastatic lesions significantly increased (P < 0.05), and was correlated with MMP-2 (X2=6.172, P = 0.0131).
Conclusions:
BCRP may play an important role in mediating liver cancer multidrug resistance to chemotherapy, and may be correlated with tumor recurrence and metastasis, which leads to weakened treatment effect. Ad-P53 can down-regulate the expression of related genes, playing a role in multidrug resistance reversal and increased sensitivity in liver cancer treatment.
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