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Structure and function of the T3/T cell receptor complex.

C Terhorst

    Behring Institute Mitteilungen
    |August 1, 1985
    PubMed
    Summary
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    The T3/T cell receptor complex on lymphocytes involves variable alpha/beta chains for antigen recognition and invariant T3 gamma, delta, epsilon chains for signal transduction. The T3-epsilon chain may function as a calcium gate, initiating T cell responses.

    Area of Science:

    • Immunology
    • Molecular Biology
    • Cell Biology

    Background:

    • The T3/T cell receptor (TCR) complex is crucial for human thymus-derived lymphocyte function.
    • It comprises variable alpha and beta chains (TCR) and invariant gamma, delta, and epsilon chains (T3 complex).

    Purpose of the Study:

    • To elucidate the functional roles of the TCR and T3 complex components in T cell activation.
    • To investigate the involvement of calcium influx in T cell signaling.

    Main Methods:

    • Gene isolation for alpha, beta, and delta chains.
    • Functional studies analyzing T cell activation pathways.

    Main Results:

    • A division of labor exists: TCR alpha/beta chains bind antigen and MHC, while the T3 complex transduces the signal.

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  • Calcium (Ca+2) influx is proposed as a key signaling event.
  • The T3-epsilon chain is hypothesized to act as a calcium gate.

    • Conclusions:

    • The T3/TCR complex orchestrates antigen recognition and signal transduction in T cells.
    • Calcium influx is pivotal in initiating T cell responses.
    • The T3-epsilon chain's potential role as a calcium channel warrants further investigation.