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Brain cholesterol homeostasis in Wilson disease

Stefano Cacciatore1, Leonardo Tenori

  • 1Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 02115 Boston, MA, USA; Metabolomics Platform, Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders, Rovira i Virgili University, 43007 Tarragona, Spain.

Medical Hypotheses
|November 2, 2013
PubMed
Summary

Wilson disease (WD) disrupts copper metabolism, leading to its accumulation. This study hypothesizes that impaired copper balance in the brain contributes to cholesterol metabolism issues and neurological problems in WD patients.

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