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CANDIS treatment program for cannabis use disorders: findings from a randomized multi-site translational trial
E Hoch1, G Bühringer2, A Pixa3
1Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Strasse 46, Dresden 01187, Germany; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Heidelberg University, Square J5, Mannheim 68159, Germany.
This study shows a modular cognitive-behavioral intervention effectively treats cannabis use disorder (CUD) in real-world clinical settings. The treatment significantly improved abstinence rates and reduced CUD symptoms in patients.
Area of Science:
- Addiction Medicine
- Clinical Psychology
- Psychotherapy Research
Background:
- Previous research demonstrated the efficacy of a modular cognitive-behavioral intervention for cannabis use disorder (CUD).
- This study evaluated the real-world effectiveness of this intervention after its translation into clinical practice.
Purpose of the Study:
- To assess the clinical utility and outcomes of a translated modular cognitive-behavioral intervention for CUD.
- To determine the intervention's impact on abstinence rates and CUD symptom severity in a diverse patient population.
Main Methods:
- A multi-site randomized controlled trial involving 279 adult and adolescent treatment seekers with CUD.
- Participants were assigned to either Active Treatment (AT) or a Delayed Treatment Control (DTC) group.
- The AT group received 10 sessions of manualized psychotherapy combining CBT, MET, and problem-solving training, with assessments at multiple time points.
Main Results:
- Post-treatment, 53.3% of AT patients achieved abstinence compared to 22% in the DTC group (p<0.001).
- AT patients showed significant improvements in cannabis use frequency, dependence criteria, and related problems with moderate to high effect sizes.
- While abstinence rates slightly decreased at 3- and 6-month follow-ups, secondary outcome improvements were sustained.
Conclusions:
- The modular cognitive-behavioral intervention is effectively transferable to clinical practice for treating CUD.
- This evidence-based approach has the potential to enhance access to care for individuals with chronic CUD.
