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Relative contribution of cognitive and physical disability components to quality of life in MS

Jeroen Van Schependom1, Marie B D'hooghe2, Mélanie De Schepper3

  • 1UZ Jette, Center for Neurosciences, Laarbeeklaan 101, 1090, Brussels, Belgium; Faculté de Psychologie et des Sciences de l'Education, Place du parc 20, 7000, Mons, Belgium.

Journal of the Neurological Sciences
|November 2, 2013
PubMed
Abstract

Insights

Cognitive impairment in multiple sclerosis (MS) does not significantly impact overall quality of life in multivariate models. However, cognitive function remains a key predictor for daily "Usual Activities" in MS patients.

Area of Science:

  • Neurology
  • Quality of Life Research
  • Neurorehabilitation

Background:

  • Limited understanding of cognitive vs. physical impairment's effect on quality of life (QoL) in multiple sclerosis (MS).
  • Lack of scientific consensus on the relative impact of these impairments.

Purpose of the Study:

  • To investigate the distinct contributions of cognitive and physical impairments to QoL in MS patients.
  • To analyze how measures from the Multiple Sclerosis Functional Composite (MSFC) test relate to QoL.

Main Methods:

  • Utilized data from MSFC and EQ5D (EuroQol 5 Dimensions) measurements at the National MS Center Melsbroek.
  • Employed ANOVA and multilinear regression models to assess correlations between EQ5D, EQVAS (EuroQol Visual Analogue Scale), MSFC, and EDSS (Expanded Disability Status Scale) scores.

Main Results:

  • A significant univariate correlation was observed between EQVAS scores and cognitive function.
  • In multivariate models including EDSS and MSFC, cognitive function was excluded by the Akaike Information Criterion.
  • Cognitive function emerged as a significant predictor for the 'Usual Activities' domain of the EQ5D.

Conclusions:

  • Cognitive performance, specifically as measured by the PASAT-3s (Paced Auditory Serial Addition Test), does not correlate with overall perceived QoL in a multivariate MS context.
  • Despite not predicting overall QoL, cognitive function remains crucial for predicting a patient's ability to perform usual activities.
Keywords:
Cognitive impairmentEQ5DMSFCMultiple sclerosisPhysical impairmentQuality of life

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