Cyclophilin A: a key player for human disease.

Area of Science:

• Biochemistry
• Immunology
• Molecular Biology

Background:

• Cyclophilin A (CyPA) is an immunophilin protein with peptidyl prolyl cis-trans isomerase (PPIase) activity.
• Initially considered intracellular, CyPA is now known to be secreted by cells during inflammatory responses.
• Emerging evidence highlights CyPA's significant role in the pathogenesis of numerous human diseases.

Purpose of the Study:

• To review current data on the involvement of Cyclophilin A (CyPA) in various pathological conditions.
• To explore the molecular mechanisms underlying CyPA's function in disease.
• To identify potential therapeutic targets for novel pharmacological interventions.

Main Methods:

• Literature review of recent studies on Cyclophilin A (CyPA).
• Analysis of data from animal models and human studies.
• Synthesis of information regarding CyPA's role in cardiovascular diseases, viral infections, neurodegeneration, cancer, and inflammatory conditions.

Main Results:

• Cyclophilin A (CyPA) is implicated in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis, and aging.
• Secreted CyPA acts as a critical mediator in the progression of these diseases.
• Evidence supports CyPA's involvement in regulating protein folding, trafficking, and inflammatory signaling.

Conclusions:

• Cyclophilin A (CyPA) is a crucial factor in the development and progression of diverse human diseases.
• Further research into CyPA's functions will enhance understanding of disease mechanisms.
• Targeting CyPA presents a promising strategy for developing new therapeutic approaches.