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Cerebral microbleeds in patients with acute subarachnoid hemorrhage

Sang-Beom Jeon1, Gunjan Parikh, H Alex Choi

  • 1*Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, Departments of ‡Neurology and ¶Neurosurgery, Columbia University College of Physicians and Surgeons, New York, New York; §Departments of Neurology and Neurosurgery, University of Texas Medical School at Houston, Houston, Texas; ‖Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland.

Neurosurgery
|November 2, 2013
PubMed
Abstract

Insights

Cerebral microbleeds (CMBs) are frequently found in subarachnoid hemorrhage (SAH) patients and linked to diffusion-weighted imaging lesions. These findings suggest a novel mechanism of tissue injury in SAH requiring further investigation.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Cerebral microbleeds (CMBs) are common post-stroke but unstudied in subarachnoid hemorrhage (SAH).
  • Investigating CMBs in SAH is crucial for understanding stroke-related brain injury.

Purpose of the Study:

  • To determine the prevalence, patterns, predictors, and outcomes associated with CMBs in SAH patients.
  • To explore the relationship between CMBs and other SAH-related complications and patient characteristics.

Main Methods:

  • Retrospective analysis of 39 SAH patients using T2*-weighted gradient-echo imaging.
  • Assessment of CMB frequency, location, and association with clinical and imaging data, including diffusion-weighted imaging (DWI) lesions.

Main Results:

  • 46% of SAH patients exhibited CMBs, with lobar regions being the most common site.
  • CMBs were significantly associated with DWI lesions (OR, 5.24; P = .03) after adjusting for age and hypertension.
  • A trend towards higher modified Rankin Scale scores at 3 months was observed in patients with CMBs.

Conclusions:

  • CMBs are common in SAH and correlate with DWI lesions, indicating a potential new mechanism of tissue damage.
  • Further research is warranted to elucidate the clinical significance and implications of CMBs in SAH.

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