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Related Concept Videos

Non-gated Ion Channels01:24

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time

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Cooperative gating between ion channels.

Kee-Hyun Choi1

  • 1Chemical Kinomics Research Center, Future Convergence Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea. keehyun@kist.re.kr.

General Physiology and Biophysics
|November 2, 2013
PubMed
Summary
This summary is machine-generated.

Cooperative gating in ion channels, where one channel

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Cell Physiology

Background:

  • Cooperative gating, the direct coupling of ion channel gating, occurs in various channel types.
  • This phenomenon can enhance signaling or reduce noise, with recognized physiological and disease relevance.

Purpose of the Study:

  • To review the physiological roles of cooperative ion channel gating and clustering.
  • To explore the physical and molecular mechanisms underlying channel assembly and functional coupling.
  • To discuss analytical methods for studying cooperative gating.

Main Methods:

  • Review of in vitro and in vivo studies on ion channel cooperativity.
  • Discussion of proposed physical mechanisms like channel clustering and cross-linking.
  • Examination of molecular mechanisms including ion mediation, membrane effects, and allosteric interactions.

Main Results:

  • Cooperative gating and clustering are integral to channel function and signaling.
  • Physical clustering and molecular interactions mediate functional coupling between channels.
  • Various single-channel analysis methods are available for studying cooperative gating.

Conclusions:

  • Understanding cooperative gating is crucial for comprehending signal transduction and disease.
  • Channel clustering and diverse molecular mechanisms underpin functional cooperativity.
  • Advanced analytical techniques are vital for characterizing cooperative gating phenomena.