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Updated: May 6, 2026
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
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Relapsing optic neuritis: a multicentre study of 62 patients
Aurélien Benoilid1, Caroline Tilikete2, Nicolas Collongues3
1University Hospital, France Clinical Investigation Centre, INSERM 10002, France aurelienbenoilid@gmail.com.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|November 2, 2013
Summary
Relapsing optic neuritis (RON) is a distinct autoimmune condition. Two forms, RION and CRION, show different prognoses, guiding improved management strategies for this challenging optic nerve disorder.
Area of Science:
- Neuroimmunology
- Ophthalmology
- Neurology
Background:
- Optic neuritis (ON) can be an initial symptom of various neurological and systemic diseases.
- Recurrent episodes (relapsing optic neuritis, RON) with negative workups are challenging to diagnose and manage.
- RON is poorly described, necessitating further clinical characterization.
Purpose of the Study:
- To describe the clinical, laboratory, MRI, and disability course of RON in a French cohort.
- To identify distinct patient groups within RON.
- To propose a new classification system for improved management.
Main Methods:
- Multicentre, retrospective, observational study.
- Involved a cohort of 62 patients with relapsing optic neuritis.
- Clinical, laboratory, and MRI data were analyzed.
Main Results:
- Two distinct RON groups were identified: non-progressive RION (68%) and progressive CRION (32%).
- Steroid dependence was higher in the CRION group (42% vs 10%).
- Poorer long-term visual prognosis was observed in CRION and NMO-IgG-positive patients.
Conclusions:
- RON appears to be a distinct autoimmune entity, separate from MS, NMO, and vasculitis.
- A new classification system for RON is proposed.
- Early treatment of poor prognosis forms can improve management.
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