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The need for evidence based nutritional guidelines for pediatric acute lymphoblastic leukemia patients: acute and

Joyce L Owens1, Sheila J Hanson, Jennifer A McArthur

  • 1Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin/Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, M/S #681, Milwaukee, WI 53226, USA. jowens@mcw.edu.

Nutrients
|November 2, 2013
PubMed

Insights

Pediatric leukemia survival is high, but aggressive treatments cause nutrition issues. More research is needed for optimal nutritional support during and after cancer therapy.

Area of Science:

  • Pediatric Oncology
  • Clinical Nutrition
  • Biochemistry

Background:

  • Pediatric leukemia survival rates are improving, necessitating a focus on treatment side effects.
  • Children tolerate more aggressive therapies than adults, leading to unique treatment challenges.
  • Existing adult cancer treatment data cannot be directly applied to pediatric populations due to differing responses.

Purpose of the Study:

  • To review the physiology of pediatric leukemia and its impact on nutritional assessment.
  • To discuss short- and long-term nutrition-related consequences in pediatric leukemia patients.
  • To explore the role of oxidative stress and antioxidant depletion in pediatric leukemia.

Main Methods:

  • Literature review of pediatric leukemia physiology.
  • Analysis of nutrition-related adverse effects from treatment protocols.
  • Examination of studies on oxidative stress and antioxidant levels.

Main Results:

  • Pediatric leukemia treatments can lead to significant short- and long-term nutrition-related adverse effects.
  • Specific therapies deplete essential nutrient levels, particularly antioxidants.
  • The optimal nutritional strategies for pediatric leukemia patients remain undefined.

Conclusions:

  • Nutritional assessment in pediatric leukemia is complex due to disease physiology.
  • Oxidative stress and antioxidant depletion are key concerns requiring further investigation.
  • Evidence-based nutritional interventions are crucial for improving outcomes in pediatric leukemia survivors.

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