Lymphocyte subpopulations in patients with alcoholic liver disease

To determine whether abnormalities of the lymphocyte populations are associated with alcoholic liver disease, we have characterized the subpopulations of lymphocytes in 30 alcoholic patients with and without liver disease. Total T lymphocytes were decreased in patients with alcoholic hepatitis and alcoholic cirrhosis. However, T4 (helper) and T8 (suppressor/cytotoxic) cells and the T4 and T8 cell ratio were similar to the values in controls. In these patients, the sums of T4/T8 cells exceeded that of total T cells, an alteration apparently related to severe liver damage. Cells reacting with antisera to immunoglobulins (B lymphocytes) and to Dr determinants were also within the normal range. In contrast, NK/K (natural killer/killer) cells were increased in the group of patients with steatosis or without liver alteration. Increase of NK/K cells was not observed in patients who were abstinent from alcohol for a period of two weeks or more, suggesting that alcohol may have been responsible for the increase in this lymphocyte population.