Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

EEG and spectral analysis in acute hyperventilation.

J A Kennealy, P E Penovich, S E Moore-Nease

    Electroencephalography and Clinical Neurophysiology
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Atypical language cortex in the left temporal lobe: relationship to bilateral language.

    Neurology·2004
    Same author

    Rapid initiation of gabapentin: a randomized, controlled trial.

    Neurology·2001
    Same author

    The effects of epilepsy and its treatment on sexual and reproductive function.

    Epilepsia·2000
    Same author

    Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89.

    Neurology·1997
    Same author

    Spindle coma in benzodiazepine toxicity: case report.

    Clinical EEG (electroencephalography)·1985
    Same author

    Acetazolamide and cerebral oxygenation in dogs.

    Clinical and investigative medicine. Medecine clinique et experimentale·1984
    Same journal

    Coming to terms with brain waves.

    Electroencephalography and clinical neurophysiology·2014
    Same journal

    Habituation of lower leg stretch responses in Parkinson's disease.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Asymmetry of cortical excitability revealed by transcranial stimulation in a patient with focal motor epilepsy and cortical myoclonus.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Evoked isometric muscle contractions in myopathies: analysis of pathophysiological properties by different stimulus patterns.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Task-related coherence and task-related spectral power changes during sequential finger movements.

    Electroencephalography and clinical neurophysiology·2000
    Same journal

    Electrophysiological studies in mild idiopathic carpal tunnel syndrome.

    Electroencephalography and clinical neurophysiology·2000
    See all related articles

    Hyperventilation causes electroencephalogram (EEG) changes, but inspired oxygen concentration does not affect these EEG alterations or hyperventilation symptoms in healthy adults. The study found no significant differences across tested oxygen levels.

    Area of Science:

    • Neuroscience
    • Physiology
    • Respiratory Medicine

    Background:

    • Acute hypocapnia, induced by hyperventilation, reduces cerebral blood flow (CBF), increases hemoglobin's oxygen affinity, and can cause cerebral tissue hypoxia.
    • EEG slowing during hyperventilation is often attributed to cerebral hypoxia, with hyperoxia (high oxygen levels) expected to reverse these effects.

    Purpose of the Study:

    • To investigate the impact of varying inspired oxygen concentrations (16%, 21%, and 100% O2) on electroencephalogram (EEG) posterior frequencies during hyperventilation in healthy adults.
    • To determine if hyperoxia can reverse or mitigate EEG changes associated with hyperventilation-induced hypocapnia.

    Main Methods:

    • Healthy subjects (aged 23-37) underwent controlled hyperventilation to achieve an end-tidal pCO2 of 21 mm Hg for 3 minutes.

    Related Experiment Videos

  • EEG was recorded and analyzed using visual inspection and spectral analysis (total amplitude, percentile frequencies, peak frequencies).
  • Physiological parameters including respiratory measures, heart rate, saO2, and minute ventilation were monitored.

    • Main Results:

    • Significant physiological changes occurred during hypocapnia compared to eucapnia, affecting total EEG amplitude and posterior frequencies.
    • No significant differences in EEG parameters or physiological responses were observed among the different inspired oxygen concentrations (16%, 21%, 100% O2).
    • Symptoms associated with hyperventilation were also independent of the inspired oxygen concentration within the studied range.

    Conclusions:

    • The EEG alterations observed during hyperventilation in healthy adults are independent of the inspired oxygen concentration.
    • Hyperoxia does not appear to reverse or significantly alter the EEG effects of hyperventilation-induced hypocapnia in this population.
    • Hyperventilation symptoms are also not influenced by varying oxygen concentrations, suggesting other mechanisms are primarily involved.