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Steroid-binding proteins in primate plasma.

W Rosner, M M Pugeat, G P Chrousos

    Endocrinology
    |February 1, 1986
    PubMed
    Summary
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    This study compared corticosteroid-binding globulin (CBG) and testosterone-estradiol-binding globulin (TeBG) across primate groups using immunological methods. Findings reveal distinct evolutionary patterns in these binding proteins among Old World monkeys, New World monkeys, and prosimians.

    Area of Science:

    • Primate immunology
    • Protein evolution
    • Biochemistry

    Background:

    • Hormone-binding proteins like corticosteroid-binding globulin (CBG) and testosterone-estradiol-binding globulin (TeBG) play crucial roles in regulating steroid hormone bioavailability.
    • Understanding the evolutionary conservation and divergence of these proteins across primate species can provide insights into their functional adaptations.

    Purpose of the Study:

    • To comparatively analyze serum corticosteroid-binding globulin (CBG) and testosterone-estradiol-binding globulin (TeBG) in various primate groups using immunological techniques.
    • To investigate the evolutionary relationships and molecular variations of CBG and TeBG across Old World primates, New World monkeys, and prosimians.

    Main Methods:

    • Immunological comparison of serum CBG and TeBG using antihuman antisera.

    Related Experiment Videos

  • Western blot analysis of serum proteins following sodium dodecyl sulfate gel electrophoresis.
  • Assessment of cortisol-binding affinity for squirrel monkey CBG.

    • Main Results:

    • Human and chimpanzee TeBG showed immunological similarity, as did galago/lemur and rhesus/cynomologus TeBG.
    • Western blots revealed conserved TeBG molecular species patterns in New World primates, with reversed abundance in squirrel monkeys and a single band in prosimians.
    • Human and chimpanzee CBG were similar, as were rhesus/cynomologus and lemur/galago CBG.
    • Squirrel monkey CBG exhibited decreased cortisol affinity and was immunologically distant from human CBG, grouping closer to prosimian CBG.

    Conclusions:

    • Primate TeBG and CBG exhibit distinct evolutionary trajectories, with varying degrees of conservation and divergence across major primate groups.
    • Immunological and molecular analyses highlight significant differences in TeBG and CBG, particularly between New World monkeys and other primate lineages.
    • The findings suggest that primate hormone-binding proteins have undergone adaptive evolution, potentially influencing steroid hormone signaling pathways differently across species.