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Updated: May 6, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
Published on: September 14, 2016
Conformational studies of chemotactic HCO-Met-Leu-Phe-OMe analogues
G Vertuani1, M Boggian, A Breveglieri
1Department of Pharmaceutical Sciences, University of Ferrara, Via Fossato di Mortara 17/19, I-44100, Ferrara, Italy.
Abstract:
In order to investigate the proper peptide backbone conformation able to elicit a biological activity, HCO-Met-Pro-Phe-OMe, HCO-Met-Ψ[COO]Leu-Phe-OMe, and HCO-Met-OLeu-Phe-OMe, analogues of the prototypical chemotactic peptide HCO-Met-Leu-Phe-OMe, were studied by CD and IR techniques. The results obtained comparing biological and conformational data evidence the critical presence of (i) the NH group at position 2, (ii) a rather flexible backbone, (iii) the chemical structure of the central residue which can affect the stability of a possible active conformer.
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