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Adipokines protecting CKD.

Satoshi Miyamoto1, Kumar Sharma

  • 1Center for Renal Translational Medicine, University of California San Diego/Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|November 2, 2013
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease (CKD) is rising, necessitating new treatments. This review explores how hormones from fat tissue, called adipokines, impact CKD progression and renal decline risk.

Keywords:
AMPKCKDUSF-1adipokineadiponectin

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Area of Science:

  • Nephrology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Chronic kidney disease (CKD) incidence is increasing globally, often progressing to end-stage renal disease (ESRD).
  • Adipose tissue functions as an endocrine organ, secreting hormones known as adipokines.
  • Emerging evidence links specific adipokines to CKD pathogenesis and progression.

Purpose of the Study:

  • To review the role of adipokines in the progression of chronic kidney disease.
  • To highlight recent experimental and clinical findings on adipokines in CKD.

Main Methods:

  • Literature review of experimental studies.
  • Literature review of clinical studies.
  • Analysis of the impact of adipokines on renal function and decline.

Main Results:

  • Several adipokines are implicated in the mechanisms driving CKD.
  • Adipokines may serve as significant risk factors for worsening renal function.
  • Recent research provides insights into therapeutic targets related to adipokines in CKD.

Conclusions:

  • Adipokines play a crucial role in the development and progression of CKD.
  • Understanding adipokine-CKD interactions is vital for developing novel treatment strategies.
  • Targeting adipokines presents a promising avenue for managing and potentially reversing renal decline.