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Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter,
Sanping Xu1, Xueming Wan, Xiaolan Zheng
1Division of Gastroenterology, Union Hospital of Tongji Medical college, Huazhong University of Science and Technology Wuhan, China.
Objective:
To observe the improvement of functional dyspepsia (FD) after helicobacter pylori (HP) eradication in FD patients.
Methods:
644 FD patients were recruited of whom 585 completed follow up. They were divided into postprandial distress syndrome (PDS) group and epigastric pain syndrome (EPS) group. Patients with HP infection were randomly allocated into eradication group and non-eradication group. Patients in the eradication group were randomly assigned into two groups and treated with triple therapy and sequential therapy, respectively. Patients in non-eradication group and HP non-infection group were treated with Domperidone (PDS patients) or Talcid (EPS patients). Clinical symptoms were evaluated.
Results:
When compared with patients with unsuccessful HP eradication and without eradication, significant improvement in symptoms was found at 8 w, 12 w, and 26 w in patients with successful HP eradication in EPS group (P < 0.05). However, in PDS group, improvement in symptoms was comparable among patients expect at 26 w after successful HP eradication (P < 0.05). Therapeutic efficacy in patients without HP eradication was poorer than that in HP negative patients in EPS group (P < 0.05), while in PDS group, symptoms were relived at 26 w and 52 w (P < 0.05).
Conclusions:
HP is one of pathogenic factors of FD and HP eradication may benefit FD patients, regardless therapeutic regimes, especially in EPS patients.
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