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Peripheral T-cell tolerance in hosts with acute myeloid leukemia
Xiufen Chen1, Douglas E Kline, Justin Kline
1Department of Medicine; University of Chicago; Chicago, IL USA.
Abstract:
Our laboratory investigates the immune tolerance mechanisms promoted by acute myeloid leukemia (AML). In a murine AML model, we have observed that leukemia antigen-specific T cells are specifically deleted from the host, presumably following interactions with immature host antigen-presenting cells (APCs). Ongoing work focuses on identifying APC subsets that induce T-cell tolerance in AML as well as the precise mechanisms that underlie this phenomenon.
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