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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study.

Ponnada A Narayana1, Koushik A Govindarajan, Priya Goel

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease affecting the central nervous system.
  • Cortical thickness is a key neuroimaging biomarker for brain health.
  • Understanding cortical changes in early MS is crucial for disease management.

Purpose of the Study:

  • To investigate global and regional cortical thickness in relapsing-remitting MS patients.
  • To compare cortical thickness between MS patients and healthy controls.
  • To explore correlations between cortical thickness, clinical measures, and MRI lesion load.

Main Methods:

  • 3D Magnetic Resonance Imaging (MRI) data from 250 MS patients and 125 controls.
  • Automated image quality control pipeline.
  • FreeSurfer software for cortical thickness measurement.
  • Analysis of data acquired at 1.5T and 3T MRI scanners.

Main Results:

  • Significant global and regional cortical thinning observed in MS patients compared to controls.
  • Cortical thinning was more pronounced in the left hemisphere.
  • Cortical thickness showed modest correlations with Expanded Disability Status Scale (EDSS), disease duration, and T1/T2 lesion load.
  • Age-dependent cortical thinning was weaker in MS patients than controls, and stronger in males.

Conclusions:

  • Cortical thinning is a prominent feature in early relapsing-remitting MS.
  • Left hemisphere cortical changes are more significant.
  • Cortical thickness is a valuable biomarker, correlating with clinical and radiological findings.
  • MRI field strength influences the detection of age-related cortical changes.