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Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
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Disturbed resting state EEG synchronization in bipolar disorder: A graph-theoretic analysis.
Dae-Jin Kim1, Amanda R Bolbecker, Josselyn Howell
1Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405, USA.
Neuroimage. Clinical
|November 2, 2013
Summary
Bipolar disorder (BD) is linked to disrupted brain network synchronization. This study found reduced alpha-band synchronization and altered network properties in BD patients, correlating with depression severity.
Area of Science:
- Neuroscience
- Psychiatry
- Computational Neuroscience
Background:
- Bipolar disorder (BD) is characterized by mood disturbances, potentially linked to impaired brain network function.
- Functional connectivity, reflecting synchronized neural activity, is hypothesized to be disrupted in BD.
Purpose of the Study:
- To investigate alterations in neural synchronization and network properties using resting-state electroencephalogram (EEG) in bipolar disorder patients.
- To explore the relationship between these network alterations and clinical symptoms, specifically depression.
Main Methods:
- Resting-state EEG data were collected from 57 BD type-I patients and 87 healthy controls.
- Functional connectivity was quantified using synchronization likelihood (SL) across five frequency bands (delta, theta, alpha, beta, gamma).
- Graph theory analysis assessed network properties like clustering coefficient, global efficiency, and characteristic path length.
Main Results:
- BD patients exhibited decreased mean synchronization in the alpha frequency band, particularly in fronto-central and centro-parietal regions.
- Network analysis revealed reduced clustering coefficient and global efficiency, alongside an increased characteristic path length in BD patients.
- Normalized characteristic path length and small-worldness showed significant correlations with depression scores in the BD group.
Conclusions:
- Bipolar disorder is associated with impaired neural synchronization at rest.
- Resting-state functional connectivity is disrupted in BD patients, suggesting network-level abnormalities.
- These network disruptions may contribute to the pathophysiology of bipolar disorder and its associated depressive symptoms.
Keywords:
BD, bipolar disorderBipolar disorderC, clustering coefficientsDSM-IV, diagnostic and statistical manual of mental disorders, the 4th-editionDTI, diffusion tensor imaging (image)EEG, electroencephalogramEOG, electrooculogramEg, global efficiencyEl, local efficiencyElectroencephalogramFA, fractional anisotropyFDR, false discovery rateFunctional connectivityGABA, gamma-amino butyric acidGraph theoryL, characteristic path lengthMADRS, Montgomery–Asberg Depression Rating ScaleMEG, magnetoencephalogramMRI, magnetic resonance imagingNBS, network-based statisticsNC, normal healthy controlPLI, phase lag indexResting stateSCID, Structured Clinical Interview for DSM DisordersSL, synchronization likelihoodSynchronization likelihoodWASI, Wechsler Abbreviated Scale of IntelligenceWM, white matterYMRS, Young Mania Rating Scaleb, node betweenness centralityfMRI, functional magnetic resonance imagings, node strengthγ, normalized clustering coefficientsλ, normalized characteristic path lengthσ, small-worldness
