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Updated: May 6, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Abnormal white matter microstructure in children with sensory processing disorders.

Julia P Owen¹, Elysa J Marco, Shivani Desai

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, San Francisco, CA 94107, USA ; Program in Bioengineering, University of California, San Francisco, 1700 4th St., San Francisco, CA 94158, USA.

Neuroimage. Clinical

|November 2, 2013

Summary

This summary is machine-generated.

This study found that children with Sensory Processing Disorder (SPD) have reduced white matter integrity, particularly in posterior brain regions. These differences correlate with sensory and attention challenges, suggesting a biological basis for SPD.

Keywords:

Attention deficit hyperactivity disorder (ADHD)Autism Brain development Connectivity Diffusion tensor imaging (DTI)Pediatrics

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Area of Science:

Neuroscience
Developmental Psychology
Radiology

Background:

Sensory Processing Disorder (SPD) affects 5-16% of school-aged children, potentially leading to long-term developmental deficits.
Current theories suggest SPD involves sensory cortical areas and multisensory integration (MSI) regions.
The role of white matter microstructural abnormalities in SPD requires further investigation.

Purpose of the Study:

To investigate white matter microstructural abnormalities in children with SPD using diffusion tensor imaging (DTI).
To correlate white matter integrity with behavioral measures in children with SPD.

Main Methods:

DTI scans were performed on 16 boys (8-11 years) with SPD and 24 age-, gender-, handedness-, and IQ-matched controls.
Behavior was assessed using the parent-reported Sensory Profile.
Tract-based spatial statistics (TBSS) analyzed fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) for group differences and correlations.

Main Results:

Children with SPD exhibited decreased FA and increased MD and RD compared to controls.
Abnormalities were concentrated in posterior white matter tracts, including the corpus callosum, corona radiata, and thalamic radiations.
FA and RD showed significant correlations with auditory, multisensory, and inattention scores.

Conclusions:

This study is the first to demonstrate reduced white matter microstructural integrity in children with SPD.
Disrupted white matter, predominantly in posterior tracts, is linked to atypical sensory processing and integration behaviors.
Abnormal white matter integrity may represent a biological basis for SPD and help differentiate it from conditions like autism and ADHD.