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Updated: May 6, 2026

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
[Clinical application of a new titanium clip applier in transsphenoidal surgery]
Objective:
To explore the efficacy and safety of a new titanium clip applier in transsphenoidal surgery for the A specially devised surgery instrument was developed and effectively applied in the management of intercavernous sinus hemorrhage and cerebrospinal fluid (CSF) leakage in transsphenoidal surgery.
Methods:
A total of 34 consecutive patients with pituiary adenoma underwent transsphenoidal surgery via a new deep pistol-shaped clip applier versus titanium clip. It was 21 cm long with a rectangular forepart. All patients were evaluated clinically and radiologically at 24 months and magnetic resonance imaging (MRI) was performed at Months 3-18 postoperation.
Results:
The application of such a new clip applier was effective. No operation was terminated due to ineffective hemorrhage, postoperative CSF leakage or related complications. Postoperative imaging studies revealed no significant evidence of clip artifact.
Conclusion:
The technique of hemostasis and leakage clogging with such a new clip applier is safer, faster and more reliable than its conventional counterpart in achieving dural closure and intercavernous sinus hemostasis.

