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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Introduction to the Integumentary System01:25

Introduction to the Integumentary System

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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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[Vitamin D and the skin].

F Libon1, E Cavalier, A F Nikkels

  • 1Service de Dermatologie, CHU de Liège.

Revue Medicale De Liege
|November 5, 2013
PubMed
Summary

Vitamin D plays a crucial role in skin health, influencing cell processes and immune responses. Its deficiency, often linked to dermatological conditions and photoprotection, impacts various skin diseases.

Area of Science:

  • Dermatology and Endocrinology
  • Molecular Biology and Immunology

Context:

  • The skin is a primary site for vitamin D synthesis and a target organ for its hormonal actions.
  • Vitamin D influences skin cell proliferation, differentiation, and immunomodulation.
  • Dermatological conditions and photoprotection measures can lead to vitamin D deficiency.

Purpose:

  • To summarize the multifaceted role of vitamin D in skin health.
  • To review vitamin D's impact on dermatoses, skin cancers, and immune-mediated skin diseases.
  • To highlight the relationship between skin conditions, photoprotection, and vitamin D status.

Summary:

  • Vitamin D is essential for phosphocalcic homeostasis and has emerging roles in various pathologies, including cancer and autoimmune diseases.
  • The skin synthesizes and responds to vitamin D (calcitriol), which regulates critical cellular functions and immune responses.

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  • Vitamin D influences the development and treatment of numerous skin conditions, with deficiency often associated with dermatological issues and photoprotection needs.

    • Impact:

    • Provides a comprehensive overview of vitamin D's significance in dermatology.
    • Underscores the importance of maintaining adequate vitamin D levels for skin health and disease management.
    • Informs clinical practice regarding vitamin D assessment and supplementation in patients with skin diseases.